The Grand Hotel Fermoy announced its immediate closure late on Sunday night with a brief statement posted on Facebook.
The hotel said: "It is with heavy hearts and much reluctance that we say goodbye to The Grand Hotel. Over the past 12 years, we have had tremendous support from our amazing and loyal staff, our suppliers and our fabulous customers.
"Thank you for the good times and even during the tough times, we have learned so much. We take great memories of Fermoy with us. It’s not how we hoped things would turn out and, despite our best efforts, we will cease trading on Sunday 10th November."
The hotel was located on Ashe Quay in a building which was constructed in the 1870s.